An event reported by the Gospel of John but not by any of the Synoptic Gospels. John reports that Jesus was attending a wedding in Qana with his disciples for the Jewish rite of purification, and when the hosts run out of wine, Jesus' (unnamed) mother tries to persuade Jesus to help out with a miracle. According to the evangelist, Jesus becomes annoyed at the suggestion, but Jesus' mother persists, telling the servants to obey Jesus. Jesus orders the servants to fill the empty containers with water. The servants bring the filled containers to the chief waiter, and he tells the bridegroom that it is the best wine of the evening.

This is then the first miracle of Jesus mentioned in the Gospel of John, and occurs immediately after Jesus has told Nathanael at John 1:50 that "You shall see greater things than that". Describing the miracle, John uses the Greek word semeion meaning sign, or ergon meaning work, instead of the term for miracle which the synoptics normally use: dynamis - meaning act of power.   The event is the first of the seven miraculous signs by which John attests Jesus' divine status, and around which the gospel is structured.

Some Christians see the event as having genuinely been foretold, while more critical scholars see John as deliberately creating or twisting events to fit the prophecies. A number of scholars have argued that John's account of the Qana Wedding also reflects the Synoptic Gospels' parable of the Patch and the Wineskins.